Why don’t gut bacteria perish when you have a high fever?

The immune system works much more efficiently at higher temperatures.However, the defensive-enhancing effect of the fever is not noticeable for those affected. On the contrary, fever is exhausting, because heating up the organism consumes a lot of energy. The heart rate increases, the blood circulation in the skin increases and the organism gets into a lot of sweating.

Fever increases the activity of the immune system by forcing the release of various messenger substances and hormones involved in the immune system.

This process is highly complex, not yet fully explored in detail and gives rise to a number of conjectures.

The classic among the half-truths: Fever kills bacteria and viruses.

The claim is not entirely false, but the fever has only an indirect effect on microorganisms by supporting their elimination by activating the immune system.Most germs, on the other hand, can withstand the heat itself without any problems.

From 41 degrees Celsius it becomes dangerous for the organism.Not true, because fever is self-limiting. This means that the temperature does not exceed 41 degrees Celsius due to counter-regulation mechanisms.

So if you’re feeling, you’ll get healthy faster.Even the overall survival chance of infection is significantly increased with fever. Seriously ill people who do not fever therefore not only have a slowed-down healing process, but also a significantly worse prognosis.

Basically, not every colonization of the intestine with bacteria triggers a disease.The germs of the so-called intestinal flora belong to the normal ecosystem of the intestine and protect humans from infections. Antibiotic treatment can destroy this protection and thus become the cause of difisrects.

A variety of different bacteria colonizes the human intestine.

Some are useful, for example, helping to digest them by helping to break down the food ingredients. Others behave inconspicuously, so live in peaceful coexistence with us, do not benefit us, but do not harm either. But a third group can cause problems for the human organism under certain conditions.

These pathogens infect the intestinal mucosa and, for example, trigger diarrhoea 鈥?and other, potentially dangerous organ damage.

This infection can be carried out in two ways: On the one hand, foreign pathogens can be introduced, which naturally do not occur in the healthy intestinal flora.These include disease-causing strains of otherwise harmless E. coli bacteria such as EHEC (enterohaemorrhagic E. coli), EPEC (enteropathogenic E.coli), ETEC (enterotoxic E. coli) and EIEC (enteroinvasive E. coli), which are not actually found in the human intestinal flora.

Clostridium difficile, on the other hand, lives peacefully in the intestines of many healthy people without causing complications.Only when the balance of the natural intestinal flora is disturbed 鈥?for example by treatment with antibiotics 鈥?can this bacterium become dangerous. The disease-causing effect of the bacteria comes from their metabolism. This is because they produce cell-damaging toxins that can cause serious discomfort.

The toxins secreted by the bacteria destroy the intestinal cells and therefore cause bloody excretions, just like the other germs.However, they can also damage the blood cells and blood vessels of the kidneys and lead to kidney failure.

In severe gradients, the inflamed intestinal wall “sweats” the protein fibrin.This protein combines with white blood cells and dead intestinal cells to create a white layer on the intestinal wall. Doctors call this process pseudomembranous colitis. The formed conglomerate can clog the digestive organ and swell up. In this ideal breeding site, the Clostridium difficile bacteria can multiply more and more, as a result of which the intestinal walls are destroyed and ultimately sepsis 鈥?i.e. blood poisoning 鈥?threatens the entire organism.

Unlike the harmless E.coli bacteria that live in the human gut, the disease-causing E.coli strains, campylobacter and Yersinia enterocolita are found in the intestines of ruminants such as cattle, goats and sheep, but also deer and deer.

Without becoming ill themselves, the animals excrete the bacteria through the feces. By lubricating infected animals or sick people, the pathogens are transmitted to the healthy person.

However, many people already carry the germ before the outbreak of the disease.A disease usually only occurs when the intestinal flora is disturbed by the use of antibiotics or otherwise: The bacteria naturally living in the intestine are then killed and make way for a toxin-forming subgroup of the Clostridium difficile. So even with the non-body bacteria, it is not the bacteria themselves that make you sick. And the bacteria we carry in us anyway are accustomed to the temperatures in the body and also to elevated temperatures. However, these can only survive in a healthy intestinal flora.

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